Resumen de ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair

Claudia Cosentino, Domenico Grieco, Vincenzo Costanzo

• The DNA damage-induced ATM kinase is linked to the metabolic pentose phosphate pathway, thus boosting biosynthesis of nucleotide precursors required for DNA repair and stimulating generation of the anti-oxidant NADPH, which may explain neurological defects of ataxia telangiectasia patients lacking ATM function.