Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages

• Carmen G Palii ^[3] ; Carolina Perez-Iratxeta ^[3] ; Zizhen Yao ^[1] ; Yi Cao ^[1] ; Fengtao Dai ^[2] ; Jerry Davison ^[1] ; Harold Atkins ^[3] ; David Allan ^[3] ; F Jeffrey Dilworth ^[2] ; Robert Gentleman ^[1] ; Stephen J Tapscott ^[1] ; Marjorie Brand ^[2]
  1. [1] Fred Hutchinson Cancer Research Center

     Fred Hutchinson Cancer Research Center

     City of Seattle, Estados Unidos

     
  2. [2] The Sprott Center for Stem Cell Research, Department of Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
  3. [3] The Sprott Center for Stem Cell Research, Department of Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

  Mostrar afiliaciones +
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 3, 2010, págs. 494-509
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Expression of the basic helix-loop-helix transcription factor TAL1/SCL is required for erythrocyte differentiation; aberrant expression in lymphoid cells leads to oncogenic transformation. Here, global analysis of TAL1 binding in erythroid and malignant T cells identifies cell type specific functional interaction with the transcription factors RUNX and ETS1.