PICK1 inhibition of the Arp2/3 complex controls dendritic spine size and synaptic plasticity

• Yasuko Nakamura ^[1] ; Catherine L Wood ^[3] ; Andrew P Patton ^[2] ; Nadia Jaafari ^[1] ; Jeremy M Henley ^[1] ; Jack R Mellor ^[2] ; Jonathan G Hanley ^[1]
  1. [1] University of Bristol

     University of Bristol

     Reino Unido

     
  2. [2] MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, University Walk, Bristol, UK
  3. [3] MRC Centre for Synaptic Plasticity, School of Biochemistry, University of Bristol, University Walk, Bristol, UK; MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, University Walk, Bristol, UK

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 4, 2011, págs. 719-730
• Idioma: inglés
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• Resumen

  • Dendritic spine remodelling involves regulated actin dynamics and is essential for synaptic plasticity. The Arp2/3 inhibitor PICK1 is here shown to regulate spine size: inducing shrinkage during long-term depression.