Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

• Maruf M U Ali ^[1] ; Tina Bagratuni ^[1] ; Emma L Davenport ^[1] ; Piotr R Nowak ^[2] ; M Cris Silva-Santisteban ^[1] ; Anthea Hardcastle ^[1] ; Craig McAndrews ^[1] ; Martin G Rowlands ^[1] ; Gareth J Morgan ^[1] ; Wynne Aherne ^[1] ; Ian Collins ^[1] ; Faith E Davies ^[1] ; Laurence H Pearl ^[1]
  1. [1] Institute of Cancer Research

     Institute of Cancer Research

     Reino Unido

     
  2. [2] Imperial College London

     Imperial College London

     Reino Unido

     
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 5, 2011, págs. 894-905
• Idioma: inglés
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• Resumen

  • In the endoplasmic reticulum, unfolded proteins stimulate Ire1 autophosphorylation and RNase activity. The crystal structure of the dephosphorylated kinase/RNase domain of human Ire1 bound to ADP provides insight into the autophosphorylation reaction.