Resumen de STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation
Martin Muik, Marc Fahrner, Rainer Schindl, Peter Stathopulos, Irene Frischauf, Isabella Derler, Peter Plenk, Barbara Lackner, Klaus Groschner, Mitsuhiko Ikura, Christoph Romanin
Upon depletion of ER calcium stores, STIM1 and ORAI1 associate and induce calcium release-activated calcium (CRAC) currents. This study reveals that STIM1 undergoes an intramolecular transition into an extended conformation that is involved in ORAI1 binding and activation.
