The nuclear RNA polymerase II surveillance system targets polymerase III transcripts

• Wiebke Wlotzka ^[1] ; Grzegorz Kudla ^[1] ; Sander Granneman ^[1] ; David Tollervey ^[1]
  1. [1] Wellcome Trust Centre for Cell Biology

     Wellcome Trust Centre for Cell Biology

     Reino Unido

     
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 9, 2011, págs. 1790-1803
• Idioma: inglés
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• Resumen

  • The exosome and Trf4/5–Air1/2–Mtr4 polyadenylation (TRAMP) complexes together with the Nrd1–Nab3 RNA-binding heterodimer have an important role in RNA surveillance. Here, the global analysis of Nrd1, Nab3 and Trf4 binding sites identifies targets for the nuclear surveillance system, including mRNAs, ncRNAs and RNA polymerase III transcripts.