Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction

• Stefano Santaguida ^[2] ; Claudio Vernieri ^[1] ; Fabrizio Villa ^[2] ; Andrea Ciliberto ^[1] ; Andrea Musacchio ^[3]
  1. [1] FIRC Institute of Molecular Oncology

     FIRC Institute of Molecular Oncology

     Milán, Italia

     
  2. [2] Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
  3. [3] Department of Experimental Oncology, European Institute of Oncology, Milan, Italy; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 8, 2011, págs. 1508-1519
• Idioma: inglés
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• Resumen

  • Aurora B kinase corrects aberrant microtubule-chromosome attachments during mitosis. This function derives from Aurora B's role in the spindle assembly checkpoint, independently of its established role in the tension dependent microtubule-chromosome error correction mechanism.