Resumen de Histone variant macroH2A confers resistance to nuclear reprogramming

Vincent Pasque, Astrid Gillich, Nigel Garrett, John B. Gurdon

• Gurdon and collaborators report reversible X chromosome inactivation in epiblast stem cells (EpiSCs) that seems to be determined by macroH2A1 deposition. These findings are of rather general interest as they highlight the epigenetic state of repressed loci as determinant for reprogramming efficiency.