Box C/D snoRNP catalysed methylation is aided by additional pre-rRNA base-pairing

• Robert Willem van Nues ^[1] ; Sander Granneman ^[2] ; Grzegorz Kudla ^[2] ; Katherine Elizabeth Sloan ^[1] ; Matthew Chicken ^[1] ; David Tollervey ^[2] ; Nicholas James Watkins ^[1]
  1. [1] Newcastle University

     Newcastle University

     Reino Unido

     
  2. [2] Wellcome Trust Centre for Cell Biology, The University of Edinburgh, Edinburgh, UK
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 12, 2011, págs. 2420-2430
• Idioma: inglés
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• Resumen

  • Box C/D small nucleolar RNPs catalyse 2′-O-methylation of eukaryotic ribosomal RNA. A large-scale analysis of yeast box C/D snoRNAs reveals conserved ‘extra base-pairing' between snoRNAs and regions adjacent to their rRNA methylation site and points to a role for the non-catalytic protein subunits Nop56 and Nop58 in rRNA binding.