Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1

• Ewan Smith ^[1] ; Nadia Hégarat ^[1] ; Clare Vesely ^[1] ; Isaac Roseboom ^[1] ; Chris Larch ^[1] ; Hansjörg Streicher ^[1] ; Kornelis Straatman ^[2] ; Helen Flynn ^[4] ; Mark Skehel ^[4] ; Toru Hirota ^[5] ; Ryoko Kuriyama ^[3] ; Helfrid Hochegger ^[1]
  1. [1] University of Sussex

     University of Sussex

     Reino Unido

     
  2. [2] University of Leicester

     University of Leicester

     GB.ENG.H4.31UC, Reino Unido

     
  3. [3] University of Minnesota

     University of Minnesota

     City of Minneapolis, Estados Unidos

     
  4. [4] CRUK London Research Institutes Clare Hall, South Mimms, UK
  5. [5] The Cancer Institute, Japanese Foundation for Cancer Research, Ariake, Tokyo, Japan

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 11, 2011, págs. 2233-2245
• Idioma: inglés
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• Resumen

  • Mammalian centrosomes separate prior to mitosis in a process involving Cdk1 and the kinesin Eg5. Dissection by chemical genetics reveals a Cdk1-independent alternative mechanism, in which Plk1 counteracts both centrosomal cohesion factors and Eg5-opposing cytoskeletal forces.