TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis

• Monika Petersson ^[1] ; Heike Brylka ^[1] ; Andreas Kraus ^[1] ; Susan John ^[1] ; Gunter Rappl ^[1] ; Peter Schettina ^[1] ; Catherin Niemann ^[1]
  1. [1] University of Cologne

     University of Cologne

     Kreisfreie Stadt Köln, Alemania

     
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 15, 2011, págs. 3004-3018
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • This work investigates cell fate and lineages of hair follicles and sebaceous glands (SG) in the mouse epidermis. The combination of transgenic models with complementary tracing techniques provides unequivocal evidence for a direct contribution of bulge stem cells to the SG units as well as stem cell niches within the isthmus region.