Resumen de Vaccinia extracellular virions enter cells by macropinocytosis and acid-activated membrane rupture

Florian Schmitt, Christopher D. Black, Ari Helenius, Jason Mercer

• Double membrane-bound vaccinia extracellular virions actively promote their own macropinocytosis. This, followed by acid-induced rupture of the outer membrane in endocytic vesicles, exposes the inner membrane for fusion with the endocytic membrane and release into the cytosol.