Resumen de Structural basis for cell surface patterning through NetrinG–NGL interactions

Elena Seiradake, Charlotte H. Coles, Pavel V. Perestenko, Karl Harlos, Robert Andrew Jeffrey McIlhinney, Alexandru Radu Aricescu, E. Yvonne Jones

• NetrinGs and NetrinG-ligands (NGLs) control neuronal circuit development, and their dysregulation is associated with autism and schizophrenia. The first structures of NetrinG-NGL complexes and structure-based functional assays show that binding affinity governs the cell surface compartmentalization of NGLs.