Aleksandra Bochkareva, Yulia Yuzenkova, Vasisht Tadigotla, Nikolay Zenkin
RNA polymerase pausing during transcription is implicated in controlling gene expression. This study identifies a new type of pausing mechanism, by which the RNAP core recognizes the shape of base pairs of the RNA–DNA hybrid, which determines the rate of translocation and the nucleotide addition cycle. The expression of a number of viral and bacterial genes is shown to be subject to this mechanism.
© 2001-2024 Fundación Dialnet · Todos los derechos reservados