A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

• Carmine Settembre ^[4] ; Roberto Zoncu ^[7] ; Diego L Medina ^[4] ; Francesco Vetrini ^[4] ; Serkan Erdin ^[1] ; SerpilUckac Erdin ^[1] ; Tuong Huynh ^[1] ; Mathieu Ferron ^[2] ; Gerard Karsenty ^[2] ; Michel C Vellard ^[5] ; Valeria Facchinetti ^[3] ; David M Sabatini ^[6] ; Andrea Ballabio ^[4]
  1. [1] Baylor College of Medicine

     Baylor College of Medicine

     Estados Unidos

     
  2. [2] Columbia University

     Columbia University

     Estados Unidos

     
  3. [3] University of Texas MD Anderson Cancer Center

     University of Texas MD Anderson Cancer Center

     Estados Unidos

     
  4. [4] Telethon Institute Of Genetics And Medicine

     Telethon Institute Of Genetics And Medicine

     Nápoles, Italia

     
  5. [5] BioMarin Pharmaceutical Inc, Novato, CA, USA
  6. [6] Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA; David H Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, USA; 0Seven Cambridge Center, Broad Institute, Cambridge, MA, USA; 1Howard Hughes Medical Institute, MIT, Cambridge, MA, USA
  7. [7] Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA; David H Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, USA

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 5, 2012, págs. 1095-1108
• Idioma: inglés
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  • Under basal conditions TFEB, a master regulator of lysosomal biogenesis, is sequestered in the cytosol due to mTORC1-dependent phosphorylation at the lysosomal membrane. Nutrient starvation or lysosomal dysfunction inhibit mTORC1 activity and induce nuclear translocation of TFEB inducing target gene expression.