Resumen de DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

Michael Volkmar, Sarah Dedeurwaerder, Daniel A Cunha, Matladi N Ndlovu, Matthieu Defrance, Rachel Deplus, Emilie Calonne, Ute Volkmar, Mariana Igoillo-Esteve, Najib Naamane, Silvia Del Guerra, Matilde Masini, Marco Bugliani, Piero Marchetti, Miriam Cnop, Decio L Eizirik, Francois Fuks

• The first genome-scale DNA methylation study on pancreatic islets from type 2 diabetic patients identifies disease-associated DNA methylation pattern that translate into aberrant gene expression in novel factors relevant for β-cell function and survival.