Coordination of multiple enzyme activities by a single PCNA in archaeal Okazaki fragment maturation

• Thomas R Beattie ^[1] ; Stephen D Bell ^[1]
  1. [1] Sir William Dunn School of Pathology, Oxford University, Oxford, UK
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 6, 2012, págs. 1556-1567
• Idioma: inglés
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• Resumen

  • In vitro reconstitution of Okazaki fragment processing shows that DNA polymerase, flap endonuclease and DNA ligase need to simultaneously bind to the same PCNA-sliding clamp molecule during DNA lagging strand replication.