Resumen de O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

Shalini Pathak, Vladimir Borodkin, Osama Albarbarawi, D. G. Campbell, Adel F. M. Ibrahim, Daan M. F. van Aalten

• The protein kinase TAK1 plays an important role in pro-inflammatory cytokine signalling. Interleukin-1- and osmotic stress-induced O-GlcNAcylation of its regulatory subunit TAB1 is required for full TAK1 activation to induce downstream cytokine production, linking this protein modification to innate immunity signalling.