The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation

• Florencia Cano ^[3] ; Helen Bye ^[3] ; Lidia M Duncan ^[3] ; Karine Buchet-Poyau ^[1] ; Marc Billaud ^[1] ; Mark R Wills ^[2] ; Paul J Lehner ^[3]
  1. [1] Institut Albert Bonniot

     Institut Albert Bonniot

     Arrondissement de Grenoble, Francia

     
  2. [2] University of Cambridge

     University of Cambridge

     Cambridge District, Reino Unido

     
  3. [3] Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK

  Mostrar afiliaciones +
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 17, 2012, págs. 3596-3606
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • The novel RNA-binding E3 ubiquitin ligase MEX-3C targets the mRNA of MHC-I gene HLA-A2 for degradation in a RING-dependent manner. Depletion of MEX-3C in NK cells leads to reduced killing of target cells.