Resumen de Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis

Alexander J. Laarman, Gerdien Mijnheer, Joe M. Mootz, Willemien J. M. van Rooijen, Maartje Ruyken, C. l. Malone, Erik C. Heezius, Richard L. Ward, Graeme Milligan, Jos A. G. van Strijp, Carla J. C. de Haas, Alexander R. Horswill, Kok P. M. van Kessel, Suzan H. M. Rooijakkers

• Neutrophil activation and recruitment to the site of infection are critical for host immunity. In humans, the cysteine protease Staphopain A of the pathogen S. aureus blocks this process by cleaving the chemokine receptor CXCR2.