The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension

• Judith J Smit ^[2] ; Davide Monteferrario ^[1] ; Sylvie M Noordermeer ^[1] ; Willem J van Dijk ^[2] ; Bert A van der Reijden ^[1] ; Titia K Sixma ^[2]
  1. [1] Radboud University Nijmegen Medical Centre

     Radboud University Nijmegen Medical Centre

     Países Bajos

     
  2. [2] Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 19, 2012, págs. 3833-3844
• Idioma: inglés
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• Resumen

  • Like Parkin, the linear ubiquitin chain assembly complex LUBAC functions as a RING/HECT-hybrid ubiquitin ligase, but includes a unique extension that dictates linear ubiquitin linkage specificity.