Resumen de Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

Estela Area Gómez, María del Carmen Lara Castillo, Marc D. Tambini, Cristina Guardia Laguarta, Ad J. C. de Groof, Moneek Madra, Junichi Ikenouchi, Masato Umeda, Thomas D. Bird, Stephen L. Sturley, Eric A. Schon

• Alzheimer disease (AD) associated (gamma)-secretase components presenilin-1 and -2 accumulate in MAM, an LR-like ER subcompartment connected to mitochondria. MAM function increases in patients with familial or sporadic AD and may be linked to AD pathogenesis.