Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules

• Jan R T van Weering ^[1] ; Richard B Sessions ^[1] ; Colin J Traer ^[1] ; Daniel P Kloer ^[2] ; Vikram K Bhatia ^[3] ; Dimitrios Stamou ^[3] ; Sven R Carlsson ^[4] ; James H Hurley ^[2] ; Peter J Cullen ^[1]
  1. [1] University of Bristol

     University of Bristol

     Reino Unido

     
  2. [2] National Institute of Diabetes and Digestive and Kidney Diseases

     National Institute of Diabetes and Digestive and Kidney Diseases

     Estados Unidos

     
  3. [3] University of Copenhagen

     University of Copenhagen

     Dinamarca

     
  4. [4] Umeå University

     Umeå University

     Suecia

     

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 23, 2012, págs. 4466-4480
• Idioma: inglés
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• Resumen

  • A systematic analysis of the dimerization, membrane remodelling and higher order assembly properties of all 12 human SNX-BAR sorting nexins reveals how different SNX-BAR combinations allow the formation of distinct tubular subdomains from the same endosomal vacuole during cargo sorting.