TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

• Rachel Deplus ^[1] ; Benjamin Delatte ^[1] ; Marie K Schwinn ^[4] ; Matthieu Defrance ^[1] ; Jacqui Méndez ^[4] ; Nancy Murphy ^[4] ; Mark A Dawson ^[5] ; Michael Volkmar ^[1] ; Pascale Putmans ^[1] ; Emilie Calonne ^[1] ; Alan H Shih ^[2] ; Ross L Levine ^[2] ; Olivier Bernard ^[3] ; Thomas Mercher ^[3] ; Eric Solary ^[3] ; Marjeta Urh ^[4] ; Danette L Daniels ^[4] ; François Fuks ^[1]
  1. [1] Université Libre de Bruxelles

     Université Libre de Bruxelles

     Arrondissement Brussel-Hoofdstad, Bélgica

     
  2. [2] Memorial Sloan Kettering Cancer Center

     Memorial Sloan Kettering Cancer Center

     Estados Unidos

     
  3. [3] University of Paris-Sud

     University of Paris-Sud

     Arrondissement de Palaiseau, Francia

     
  4. [4] Promega Corporation, Madison, WI, USA
  5. [5] Department of Haematology, Cambridge Institute for Medical Research, Cambridge, UK; Department of Pathology, Gurdon Institute, University of Cambridge, Cambridge, UK

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 32, Nº. 5, 2013, págs. 645-655
• Idioma: inglés
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• Resumen

  • This paper identifies the N-acetylglucosamine transferase OGT as binding partner for TET2/3 proteins. Their genome-wide chromatin binding and the characterization of the Set1/COMPASS complex as OGT target implies coordinated gene regulation.