Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels

• Ludovic Sauguet ^[3] ; Frédéric Poitevin ^[1] ; Samuel Murail ^[1] ; Catherine Van Renterghem ^[4] ; Gustavo Moraga-Cid ^[4] ; Laurie Malherbe ^[3] ; Andrew W Thompson ^[5] ; Patrice Koehl ^[2] ; Pierre-Jean Corringer ^[4] ; Marc Baaden ^[1] ; Marc Delarue ^[6]
  1. [1] Université Denis Diderot

     Université Denis Diderot

     París, Francia

     
  2. [2] UC Davis Children's Hospital

     UC Davis Children's Hospital

     Estados Unidos

     
  3. [3] Unité de Dynamique Structurale des Macromolécules, Institut Pasteur, CNRS UMR3528, Paris, France; G5 Récepteurs-Canaux, Institut Pasteur, CNRS URA2182, Paris, France
  4. [4] G5 Récepteurs-Canaux, Institut Pasteur, CNRS URA2182, Paris, France
  5. [5] Synchrotron Soleil, Saint Aubin, France
  6. [6] Unité de Dynamique Structurale des Macromolécules, Institut Pasteur, CNRS UMR3528, Paris, France

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 32, Nº. 5, 2013, págs. 728-741
• Idioma: inglés
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• Resumen

  • The high-resolution crystal structure of a pentameric ligand-gated ion channel reveals that hydroxylated residues and two water pentagon rings form an ion selectivity filter, explaining ion transport across hydrophobic constriction barriers.