Immune Response Signaling: Combinatorial and Dynamic Control

• Autores: Alexander Hoffmann
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 37, Nº. 9, 2016, págs. 570-572
• Idioma: inglés
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• Resumen

  • Macrophages mount complex responses to pathogens. Although several key signaling pathways have been identified, it remains unclear how they work together to provide specificity. In a recent paper, Gottschalk et al. report that differential dose–response behaviors of the NFκB and MAPK pathways allow dose-specific gene expression programs.