Antitissue Transglutaminase IgA for Celiac Disease Testing

• Autores: Benjamin Lebwohl, Peter H. R. Green
• Localización: JAMA: the journal of the American Medical Association, ISSN 0098-7484, Vol. 315, Nº. 1, 2016, págs. 81-82
• Idioma: inglés
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• Resumen

  • A 23-year-old woman presented for assessment of positive celiac disease serologic testing. The testing was performed at the patient’s request because her 15-year-old brother was diagnosed with celiac disease. Based on her test results, the patient was advised to commence a gluten-free diet. However, she believed that a small intestinal biopsy would be appropriate to confirm her diagnosis and sought another opinion.

    The patient did not report any symptoms. She was the eldest of 6 children who were healthy except for the 1 sibling with celiac disease. Her mother had a history of thyroid cancer. Results of her physical examination were normal except for dental enamel defects (with both color and structural changes; Figure). Her body mass index (calculated as weight in kilograms divided by height in meters squared) was 21, and her level of 25-hydroxyvitamin D was low at 18 ng/mL (reference range, 20-50). There was no evidence of other vitamin or mineral deficiency, anemia, or thyroid dysfunction.