Genetics of Lumbar Disk Degeneration: Technology, Study Designs, and Risk Factors

• Autores: Patrick Yu-Ping Kao, Danny Chan, Dino Samartzis, Pak Chung Sham, You-Qiang Song
• Localización: Orthopedic Clinics of North America, ISSN 0030-5898, Vol. 42, Nº. 4, 2011, págs. 479-486
• Idioma: inglés
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• Resumen

  • Lumbar disk degeneration (LDD) is a common musculoskeletal condition. Genetic risk factors have been suggested to play a major role in its cause. This article reviews the main research strategies that have been used to study the genetics of LDD, and the genes that thus far have been identified to influence susceptibility to LDD. With the rapid progress in genomic technologies, further advances in the genetics of LDD are expected in the next few years.