Tubulo-interstitial disorders

• Autores: Simon Ball
• Localización: Medicine, ISSN-e 1357-3039, Vol. 43, Nº. 9, 2016, págs. 517-519
• Idioma: inglés
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• Resumen

  • Chronic kidney disease (CKD) is accompanied by interstitial fibrosis and tubular atrophy (IFTA), irrespective of the underlying cause. Disorders of the vasculature, glomeruli or urinary drainage all culminate in chronic tubulo-interstitial injury, the severity of which is the histological feature that correlates best with progression to end-stage renal disease (ESRD). However, there are diverse conditions in which the tubulo-interstitium is the primary site of pathology. These may be considered together without inferring common aetiology or pathogenesis. The diseases classified as tubulo-interstitial nephritis are considered in this article.