Aurora-A: an expedition to the pole of the spindle in Xenopus egg extracts

• Jacek Z. Kubiak ^[1] ; Claude Prigent ^[1]
  1. [1] Université de Rennes
• Localización: International journal of developmental biology, ISSN 0214-6282, Vol. 60, Nº. Extra 7-9, 2016 (Ejemplar dedicado a: Special Issue: Cell-free Extracts in Development & Cancer Research / coord. por Jacek Z. Kubiak), págs. 255-261
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • The aim of this short review is to describe the contribution of Xenopus laevis egg extracts to the discovery and understanding of the regulation and function of the serine/threonine kinase Aurora-A. The power of these extracts to recapitulate cell cycle events makes them a precious tool to decipher complex biological processes at the molecular level, including the mechanisms that affect Aurora-A (post-translational modifications) and mechanisms in which Aurora-A plays a crucial role (bipolar spindle assembly). We focus on the results obtained in cell-free extracts, but we also give an updated overview of Aurora A functions found in other systems.