Most microbe-specific naïve CD4+ T cells produce memory cells during infection

• Autores: Noah J. Tubo, Brian T. Fife, Antonio J. Pagan, Dmitri I. Kotov
• Localización: Science, ISSN 0036-8075, Vol. 351, Nº 6272, 2016, págs. 511-514
• Idioma: inglés
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• Resumen

  • Infection elicits CD4+ memory T lymphocytes that participate in protective immunity. Although memory cells are the progeny of naïve T cells, it is unclear that all naïve cells from a polyclonal repertoire have memory cell potential. Using a single-cell adoptive transfer and spleen biopsy method, we found that in mice, essentially all microbe-specific naïve cells produced memory cells during infection. Different clonal memory cell populations had different B cell or macrophage helper compositions that matched effector cell populations generated much earlier in the response. Thus, each microbe-specific naïve CD4+ T cell produces a distinctive ratio of effector cell types early in the immune response that is maintained as some cells in the clonal population become memory cells.