Cells of a common developmental origin regulate REM/non-REM sleep and wakefulness in mice

• Autores: Yu Hayashi, Mitsuaki Kashiwagi, Kosuke Yasuda
• Localización: Science, ISSN 0036-8075, Vol. 350, Nº 6263, 2015, págs. 957-961
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Mammalian sleep comprises rapid eye movement (REM) sleep and non-REM (NREM) sleep. To functionally isolate from the complex mixture of neurons populating the brainstem pons those involved in switching between REM and NREM sleep, we chemogenetically manipulated neurons of a specific embryonic cell lineage in mice. We identified excitatory glutamatergic neurons that inhibit REM sleep and promote NREM sleep. These neurons shared a common developmental origin with neurons promoting wakefulness; both derived from a pool of proneural hindbrain cells expressing Atoh1 at embryonic day 10.5. We also identified inhibitory γ-aminobutyric acid–releasing neurons that act downstream to inhibit REM sleep. Artificial reduction or prolongation of REM sleep in turn affected slow-wave activity during subsequent NREM sleep, implicating REM sleep in the regulation of NREM sleep.