Synthesizing Substituted 2-Amino-2-chromenes Catalyzed by Tertiaryamine-Functionalized Polyacrylonitrile Fiber for Students To Investigate Multicomponent Reactions and Heterogeneous Catalysis

• Yujia Xie ^[1] ; Xiaoxing Liu ^[1] ; Minli Tao ^[1]
  1. [1] Tianjin University

     Tianjin University

     China

     
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 93, Nº 12, 2016, págs. 2074-2079
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • A multistep experiment for a synthesis laboratory course that incorporates topics in organic synthesis, chemical analysis, and instrumental analysis was developed. Students prepared a tertiaryamine-functionalized polyacrylonitrile fiber (PANTF), and it was subsequently utilized as an immobilized catalyst in a three-component condensation reaction among an aromatic aldehyde, malononitrile, and α-naphthol in ethanol to synthesize substituted 2-amino-2-chromenes in one pot. The fiber catalyst exhibits the advantages of high yield, excellent recyclability and reusability, simple post-treatment, and environmental friendliness. Thus, students were able to apply the concept of green chemistry through catalysis. Moreover, this comprehensive experiment involves a number of unit operations, such as vacuum distillation, filtration, recrystallization, and acid–base titration, which can train the fundamental operation capability of students, and improve their experimental skills.