Establishing Tolerance to Commensal Skin Bacteria: Timing Is Everything

• Autores: Tiffany C. Scharschmidt
• Localización: Dermatologic clinics, ISSN 0733-8635, Vol. 35, Nº. 1, 2017 (Ejemplar dedicado a: Basic Science Insights into Clinical Puzzles), págs. 1-9
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Commensal bacteria live intimately and in constant dialogue with skin immune cells. Regulating our immune response to these bacteria is critical for skin homeostasis. Using a new murine model to track Staphylococcus epidermidis-specific T cells, we found that colonization during neonatal but not adult life led to S.epidermidis-specific immune tolerance. This tolerance protected against skin inflammation and was mediated by a wave of regulatory T cells entering neonatal skin. These findings provide new insight into how we establish a healthy symbiosis with commensal microbes and highlight avenues for future research to identify novel therapies for inflammatory skin disease.