Development of a Library Search-Based Screening System for 3,4- Methylenedioxymethamphetamine in Ecstasy Tablets Using a Portable Near-Infrared Spectrometer

• Kenji Tsujikawa ^[1] ; Tadashi Yamamuro ^[1] ; Kenji Kuwayama ^[1] ; Tatsuyuki Kanamori ^[1] ; Yuko T. Iwata ^[1] ; Kazuna Miyamoto ^[2] ; Fumiyo Kasuya ^[2] ; Hiroyuki Inoue ^[1]
  1. [1] National Research Institute of Police Science

     National Research Institute of Police Science

     Japón

     
  2. [2] Biochemical Toxicology Laboratory Faculty of Pharmaceutical Sciences Kobegakuin University Kobe Hyogo Japan
• Localización: Journal of forensic sciences, ISSN-e 1556-4029, ISSN 0022-1198, Vol. 61, Nº. 5, 2016, págs. 1208-1214
• Idioma: inglés
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• Resumen

  • This is the first report on development of a library search-based screening system for 3,4-methylenedio xymethamphetamine (MDMA) in ecstasy tablets using a portable near-infrared (NIR) spectrometer. The spectrum library consisted of spectra originating from standard substances as well as mixtures of MDMA hydrochloride (MDMA-HCl) and diluents. The raw NIR spectra were mathematically pretreated, and then, a library search was performed using correlation coefficient. To enhance the discrimination ability, the wavelength used for the library search was limited. Mixtures of MDMA-HCl and diluents were used to decide criteria to judge MDMA-positive or MDMA-negative. Confiscated MDMA tablets and medicinal tablets were used for performance check of the criteria. Twenty-two of 27 MDMA tablets were truly judged as MDMA-positive. Five false-negative results may be caused by compounds not included in the library. No false-positive results were obtained for medicinal tablets. This system will be a useful tool for on-site screening of MDMA tablets.