Chapter Eight - Current Approaches to the Treatment of Atrial Fibrillation

• Autores: Heather Finlay
• Localización: Annual reports in medicinal chemistry, ISSN 0065-7743, Vol 49, 2014, págs. 101-113
• Idioma: inglés
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• Resumen

  • Abstract Atrial fibrillation (AF) is a condition characterized by rapid and irregular sinus rhythm which leads to a higher incidence of stroke and increased mortality. AF affects approximately 1% of the worldwide population, and despite significant advances in anticoagulation therapy, AF patients remain in abnormal sinus rhythm. There is a demonstrated benefit to restoring and maintaining normal sinus rhythm in addition to preventing thromboembolic events, and the discovery of anti-arrhythmic agents with improved efficacy and safety has been a continued and active area of research in the pharmaceutical industry. Recent clinical and preclinical advances in the atrial-selective IKur and IKAch ion channel targets are summarized in this review covering disclosures from 2010 to 2014.