Chronic Alcohol Abuse Leads to Low Bone Mass with No General Loss of Bone Structure or Bone Mechanical Strength

• Maiken Parm Ulhøi ^[4] ; Karoline Meldgaard ^[1] ; Torben Steiniche ^[2] ; Anders Odgaard ^[3] ; Annie Vesterby ^[4]
  1. [1] Regional Hospital West Jutland

     Regional Hospital West Jutland

     Dinamarca

     
  2. [2] Aarhus University Hospital

     Aarhus University Hospital

     Dinamarca

     
  3. [3] Copenhagen University Hospital

     Copenhagen University Hospital

     Dinamarca

     
  4. [4] University of Aarhus Arhus N Denmark

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• Localización: Journal of forensic sciences, ISSN-e 1556-4029, ISSN 0022-1198, Vol. 62, Nº. 1, 2017, págs. 131-136
• Idioma: inglés
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• Resumen

  • Chronic alcohol abuse (CAA) has deleterious effects on skeletal health. This study examined the impact of CAA on bone with regard to bone density, structure, and strength. Bone specimens from 42 individuals with CAA and 42 individuals without alcohol abuse were obtained at autopsy. Dual-energy X-ray absorptiometry (DEXA), compression testing, ashing, and bone histomorphometry were performed. Individuals with CAA had significantly lower bone mineral density (BMD) in the femoral neck and significantly lower bone volume demon- strated by thinner trabeculae, decreased extent of osteoid surfaces, and lower mean wall thickness of trabecular osteons compared to individuals without alcohol abuse. No significant difference was found for bone strength and structure. Conclusion: CAA leads to low bone mass due to a decrease in bone formation but with no destruction of bone architecture nor a decrease in bone strength. It is questionable whether this per se increases fracture risk.