Resumen de Fluoride concentration and pH of pediatric medicines regulary and long-term used by children

Isabela Albuquerque Passos, Cláudia Helena Soares de Freitas, Fábio Correia Sampaio

• Objectives: Our aim in this study was to determine the fluoride concentration and pH of 71 pediatric medicines regularly and long-term used by children.

  Study Design: The fluoride concentration was evaluated by selective electrode of fluoride (Orion). The pH was confronted using specific electrode (Orion) coupled to a potentiometer (Orion). The analyses were accomplished in duplicate. Pearson´s correlation and Kruskal-Wallis test were used. P-values below 5% were considered statistically significant.

  Results: Medicine pH averages ± SD varied from 2.3 ±0.01 to up 10.6 ±0.02. Values below critical pH were observed in 42.25% (n=30) of presentations, with 25.35% (n=18) below 4.5 pH. Most medicines (84.5%) presented fluoride concentration below 0.05 mg/L.

  Conclusions: Among the pediatric medicines evaluated, this study has showed that 2-4 times-a-day posology and syrup formulations presented lowest pH and fluoride concentration, resulting in factors that predict highest cariogenic and erosive potential.