Resumen de Variations of interleukin-6 after surgical removal of lower third molars

Carmen López Carriches, José María Martínez González, Manuel Donado Rodríguez

• español

  Objetivos: Determinar si tras la cirugía del tercer molar inferior se produce una liberación de interleuquina-6 (IL-6) y comparar la cantidad de IL-6 en pacientes que tomaron AINES y en aquellos que tomaron glucocorticoides.

  Diseño del estudio: Estudio prospectivo sobre 73 pacientes sometidos a la extracción quirúrgica de los terceros molares inferiores. Fueron divididos en dos grupos: De diclofenaco y de metilprednisolona. Se recogieron muestras de fluído crevicular gingival para valorar la liberación de interleuquina-6 tras la cirugía. Se usó el programa estadístico BMDP para hacer un amplio tratamiento de los datos.

  Resultados: Los niveles de IL-6 se elevaron tras la cirugía del tercer molar inferior permaneciendo elevados al séptimo día del postoperatorio, elevándose más a las 24 horas en el grupo de diclofenaco siendo esta diferencia significativa (0,008).

  Conclusiones: La IL-6 se eleva tras la cirugía del tercer molar inferior, presentando diferente comportamiento en los dos grupos de estudio.

• English

  Objectives: To determine if there is a release of IL-6 after surgical removal of lower third molars and to compare the amount of IL-6 in patients treated with NSAID and in those treated with glucocorticoids.

  Study Design: Prospective study on 73 patients who attended the Oral Surgery Unit (Department of Medicine and Oral Surgery) in the Faculty of Odontology of the Universidad Complutense de Madrid for the surgical removal of their lower third molars. These patients were separated into two groups: the diclofenac group and the methylprednisolone group. A record card was completed with preoperative and postoperative epidemiological and clinic data. Samples of gingival crevicular fluid were collected in order to assess the release of interleukin-6 after surgery. In order to make a broad study of data, the BMDP program was used for statistical analysis.

  Results: Levels of IL-6 were higher after surgical extraction of lower third molars and remained high until the seventh day after. Levels were higher in the diclofenac group 24 hours after surgery, the difference was significant (0.008).

  Conclusions: IL-6 is higher after surgical extraction of lower third molars, behaving differently in each of the groups.