Autoimmune Cardiotoxicity of Cancer Immunotherapy

• Autores: Feixiong Cheng, Joseph Loscalzo
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 38, Nº. 2, 2017, págs. 77-78
• Idioma: inglés
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• Resumen

  • Contemporary immunotherapies (e.g., immune checkpoint inhibitors), which enhance the immune response to cancer cells, improve clinical outcomes in several malignancies. A recent study reported the cases of two patients with metastatic melanoma who developed fatal myocarditis during ipilimumab and nivolumab combination immunotherapy; these examples highlight the risk of unbridled activation of the immune system.