NKG2D Signaling: The Immune Subversive Side of HDAC3

• Autores: Alicia R. Folgueras, Segundo González, Alejandro López Soto
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 38, Nº. 3, 2017, págs. 151-153
• Idioma: inglés
• Enlaces
  • Texto Completo Ejemplar
• Resumen

  • Natural killer (NK) cells are alerted to infected and transformed cells by local upregulation of ligands for the NK-activating receptor NKG2D. In a recent report, Greene et al. unveil a new mechanism that induces the expression of the NKG2D ligand retinoic acid early-inducible (RAE-1) in response to murine cytomegalovirus (MCMV) infection through inhibition of casein kinase 2 (CK2), an activator of the repressor histone deacetylase HDAC3.