Picking the Survivor!: CRISPR Reveals HIV Dependency Factors

• Autores: Kerstin Schott, Renate König
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 25, Nº. 4, 2017, págs. 243-245
• Idioma: inglés
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• Resumen

  • A new study employs genome-wide loss-of-function CRISPR/Cas9 screening to identify three novel factors for HIV-1 entry. The factors represent promising targets for therapeutics as they are essential for HIV-1 infection, but dispensable for cell survival. The involved pathways were validated in primary CD4+ T cells, target cells for HIV-1.