Transcriptional addiction in cancer

• James Bradner ; Denes Hnisz ; Richard A. Young ^[1]
  1. [1] Whitehead Institute for Biomedical Research
• Localización: Cell, ISSN 0092-8674, Vol. 168, Nº. 4, 2017 (Ejemplar dedicado a: Cancer, the road ahead), págs. 629-643
• Idioma: inglés
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• Resumen

  • Cancer arises from genetic alterations that invariably lead to dysregulated transcriptional programs. These dysregulated programs can cause cancer cells to become highly dependent on certain regulators of gene expression. Here, we discuss how transcriptional control is disrupted by genetic alterations in cancer cells, why transcriptional dependencies can develop as a consequence of dysregulated programs, and how these dependencies provide opportunities for novel therapeutic interventions in cancer.