Understanding the intersections between metabolism and cancer biology

• Matthew G. Vander Heiden ^[1] ; Ralph J. DeBerardinis ^[2]
  1. [1] Massachusetts Institute of Technology

     Massachusetts Institute of Technology

     City of Cambridge, Estados Unidos

     
  2. [2] University of Texas Southwestern Medical Center

     University of Texas Southwestern Medical Center

     Estados Unidos

     
• Localización: Cell, ISSN 0092-8674, Vol. 168, Nº. 4, 2017 (Ejemplar dedicado a: Cancer, the road ahead), págs. 657-669
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical benefit requires defining the pathways that are limiting for cancer progression and understanding the context specificity of metabolic preferences and liabilities in malignant cells. Progress toward answering these questions is providing new insight into cancer biology and can guide the more effective targeting of metabolism to help patients.