Hepatocellular Adenomas: Morphology and Genomics

• Autores: Paulette Bioulac-Sage, Christine Sempoux, Charles Balabaud
• Localización: Gastroenterology clinics of North America, ISSN 0889-8553, Vol. 46, Nº. 2, 2017 (Ejemplar dedicado a: Liver Pathology), págs. 253-272
• Idioma: inglés
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• Resumen

  • Hepatocellular adenomas (HCAs) are rare benign tumors. This single entity has been split into 3 subtypes corresponding to specific mutations: HNF1α-inactivated HCA; inflammatory HCA related to different mutations, all leading to activation of STAT3 pathway; and β-catenin–activated HCA related to CTNNB1 mutations. The risk of malignant transformation depends on the level of β-catenin activation, reported mainly for exon 3, including S45. It is possible using specific immunohistochemical markers to identify the 3 different HCA subtypes and the level of β-catenin activation. Fewer than 10% of HCAs remain unclassified.