Hepatitis E Virus and the Liver: Clinical Settings and Liver Pathology

• Autores: Daniela Lenggenhager, Achim Weber
• Localización: Gastroenterology clinics of North America, ISSN 0889-8553, Vol. 46, Nº. 2, 2017 (Ejemplar dedicado a: Liver Pathology), págs. 393-407
• Idioma: inglés
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• Resumen

  • Infection with hepatitis E virus (HEV) is a leading cause of acute hepatitis worldwide, now increasingly recognized also in nonendemic regions. Clinical manifestation of hepatitis E includes mostly asymptomatic/subclinical presentations or acute, self-limiting hepatitis, but also potentially fatal liver failure or chronic hepatitis in immunocompromised individuals. Accordingly, hepatitis E histolpathologic patterns range from an unremarkable histology over acute (cholestatic) hepatitis with variable degree of necrosis to chronic hepatitis with fibrosis. Awareness of hepatitis E and its differential diagnoses, knowledge of its clinico-pathologic manifestations and familiarity with its diagnostic tools will enable clinicians and pathologists to competently make this diagnosis.