Diagnosis of Bacterial Infection Using a 2-Transcript Host RNA Signature in Febrile Infants 60 Days or Younger

• Autores: Myrsini Kaforou, Jethro A. Herberg, Victoria J. Wright
• Localización: JAMA: the journal of the American Medical Association, ISSN 0098-7484, Vol. 317, Nº. 15, 2017, págs. 1577-1578
• Idioma: inglés
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• Resumen

  • Distinguishing children with potentially life-threatening bacterial infections from febrile children with viral infections remains a major challenge. Herberg and colleagues,1 in a preliminary, cross-sectional study of 370 febrile children (aged <17 years) in Europe and the United States, reported that children with bacterial infection may be characterized by the difference in blood RNA expression values of 2 genes. In a recent study, Mahajan and colleagues2 reported a 66-transcript blood RNA signature that distinguished bacterial from viral infection in 279 febrile infants younger than 60 days. Young infants are at high risk of bacterial infection; diagnosis is difficult and prompt treatment important. To provide further validation of the 2-gene signature and to evaluate its performance in the infant population, we applied the signature to the RNA expression data of Mahajan et al.