Interoperability applied to pharmaceutical care in patients with renal failure: Effectiveness and safety of drug dosing

• Autores: Marta Gallego Úbeda, María Angeles Campos Fernández de Sevilla, Laura Delgado Téllez, Amaia Egües Lugea, Irene Iglesias Peinado, Federico Tutau Gómez
• Localización: European journal of clinical pharmacy: atención farmacéutica, ISSN 2385-409X, Vol. 19, Nº. 1, 2017, págs. 41-47
• Idioma: inglés
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• Resumen

  • Background: The complexity of the use of drugs in patients with kidney disease requires developing methodologies for efficient care avoiding Drug Related Problems (DRP). Objectives: To evaluate the effectiveness and safety of Pharmaceutical Interventions (PI) in patients with Renal Failure (RF) and drugs that require adjustment in RF. Method: retrospective and controlled study. A software (SONAR) based on interoperability (integration of information from different applications) was applied at three periods: PO: prior to tool implementation; P1 : at the beginning of the implementation, P2: one year after implementation. Effectiveness and safety analysis was made in levofloxacin, metoclopramide, ranitidine and metformin (these drugs were common to all three periods and had a broad number of PI). Results: For selected drugs: the drug's toxicity in accepted PI is reduced (p <0.05) while maintaining effectiveness (p >0.05). PI most relevant were in levofloxacin, women, cardiovascular disease, advanced age patient (>87 years) and treatment >10 days. Conclusion: SONAR decreases toxicity while maintaining the effectiveness of the drugs in those patients in which PI were made. Increases the detection efficiency of DRP. Replacing the limited evidence on clinical impact of PI in patients with RF