p62 in cancer: signaling adaptor beyond autophagy

• Jorge Moscat Guillén ; Michael Karin ^[1] ; María Diaz-Meco
  1. [1] University of California
• Localización: Cell, ISSN 0092-8674, Vol. 167, Nº. 3, 2016, págs. 606-609
• Idioma: inglés
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• Resumen

  • Adaptor proteins participate in selective autophagy, which is critical for cellular detoxification and stress relief. However, new evidence supports an autophagy-independent key role of the adaptor p62 (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in the epithelium and suppression of tumor progression in the stroma.