Finally, Archaea Get Their CRISPR-Cas Toolbox

• Autores: Uri Gophna , Thorsten Allers, Anita Marchfelder
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 25, Nº. 6, 2017, págs. 430-432
• Idioma: inglés
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• Resumen

  • The majority of archaea encode CRISPR-Cas systems but only a few CRISPR-Cas-based genetic tools have been developed for organisms from this domain. Nayak and Metcalf have harnessed a bacterial Cas9 protein for genome editing in Methanosarcina acetivorans, enabling efficient gene deletion and replacement.